Grapefruit can increase the amount of this medication in your bloodstream. Consult your doctor or pharmacist for more details. If you also take certain other drugs to lower your cholesterol bile acid-binding resins such as cholestyramine or colestipol , take this product at least 2 hours before or at least 4 hours after taking these medications.

These medications can react with this product, preventing its full absorption. Take this medication regularly in order to get the most benefit from it. Concomitant administration of strong CYP3A4 inhibitors e. Concomitant administration of gemfibrozil, cyclosporine, or danazol [see Warnings and Precautions 5. Hypersensitivity to any component of this medication [see Adverse Reactions 6.

Active liver disease or unexplained persistent elevations in hepatic transaminase levels [see Warnings and Precautions 5. Women who are pregnant or may become pregnant. Serum cholesterol and triglycerides increase during normal pregnancy, and cholesterol or cholesterol derivatives are essential for fetal development. Because HMG-CoA reductase inhibitors statins , such as simvastatin, decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, Vytorin may cause fetal harm when administered to a pregnant woman.

Atherosclerosis is a chronic process and the discontinuation of lipid-lowering drugs during pregnancy should have little impact on the outcome of long-term therapy of primary hypercholesterolemia. There are no adequate and well-controlled studies of Vytorin use during pregnancy; however, in rare reports congenital anomalies were observed following intrauterine exposure to statins.

In rat and rabbit animal reproduction studies, simvastatin revealed no evidence of teratogenicity. Vytorin should be administered to women of childbearing age only when such patients are highly unlikely to conceive.

If the patient becomes pregnant while taking this drug, Vytorin should be discontinued immediately and the patient should be apprised of the potential hazard to the fetus [see Use in Specific Populations 8. The study found a greater reduction in cholesterol from using Vytorin than in Zocor alone. Cholesterol was reduced by 41 percent in the Zocor group and by 58 percent in the Vytorin group. However, the study did not find a difference, between the two groups, in the growth of plaque in the arteries slowing down.

The American Heart Association determined that the study was not large enough, or over a long enough period of time, to assess whether Vytorin was more or less effective than Zocor alone in reducing the risk of having a heart attack or death. There was also some controversy over the release of results, as the manufacturer of Vytorin and Zetia ezetimibe did not release results when they were scheduled to, stating they wanted to continue to analyze data from the trial.

In general, it has not been proven unsafe to take Vytorin. However, the risk versus benefit of prescribing a medication is extremely patient specific and ultimately based on your health status, medical and family history and current medication regimen. For more specific information, consult with your doctor or pharmacist for guidance based on your health status and current medications, particularly before taking any action.

I've had two open heart surgeries, I take Vytorin and my cholesterol is I have constant body pain. Should I stop Vytorin and switch to red yeast rice? Simvastatin belongs to a class of drugs called HMG-CoA reductase inhibitors, more commonly referred to as statins. Statins work by blocking the production of cholesterol in the body.

Simvastatin lowers low-density lipoprotein LDL or bad cholesterol and triglyceride levels, while increasing high-density lipoprotein HDL or good cholesterol levels. Improving your cholesterol levels can help prevent heart attack, stroke, and vascular disease.

Common side effects of statins include mild nausea, stomach pain, stomach upset, heartburn, bloating, gas, mild muscle aches, constipation, and headache.

These include liver problems and a side effect called rhabdomyolysis. Contact your doctor immediately if you have symptoms of either one of these side effects. Symptoms of liver problems include nausea, stomach pain, loss of appetite, low fever, dark urine, clay-colored stools, and jaundice yellowing of the eyes or skin.

Symptoms of rhabdomyolysis include unexplained muscle pain or tenderness, muscle weakness, fever, flu-like symptoms, and dark urine. If you are experiencing any muscle pain, contact your doctor for proper evaluation. Your doctor is best able to determine if you are experiencing a serious side effect or not.

Since red yeast rice contains some of the same active chemicals as statin drugs, do not take red yeast rice if your doctor stops your statin medication. For more specific information, consult with your doctor or local pharmacist for guidance based on your health status and current medications, particularly before taking any action. You can browse Drugs A-Z for a specific prescription or over-the-counter drug or look up drugs based on your specific condition.

This information is for educational purposes only, and not meant to provide medical advice, treatment, or diagnosis. Remember to always consult your physician or health care provider before starting, stopping, or altering a treatment or health care regimen. Every effort has been made to ensure that the information provided by on this page is accurate, up-to-date, and complete, but no guarantee is made to that effect.

Drug information contained herein may be time sensitive. There are some health risks involved when taking Vytorin with other drugs, such as Colchicine, Lomitapide, Fenofibrate, fenofibric acid, Warfarin, Coumadin, Jantoven, Amiodarone, heart or blood pressure medicine or drugs containing niacin, or vitamin B3.

Take only as directed by your doctor. Do not take Vytorin unless it was prescribed to you, even if you have high cholesterol. Tell your doctor if you have active liver disease, an abnormal liver function test, or are pregnant or nursing.

If you forget to take a dose, take it as soon as you remember. If it is close to your next scheduled dose, skip it. Do not take a double dose to catch up. If you overdose, seek medical attention immediately by calling poison control or visiting an emergency room. Do not get pregnant while taking Vytorin. Speak to your doctor if you suspect that you are pregnant. Women who are pregnant or breastfeeding should inform their doctor about their condition. Women of a childbearing age should use effective birth control methods to prevent a pregnancy during the course of treatment.

Vytorin Dosage The drug is available in the form of tablets that need to taken orally. The tablets are available in four different strengths: All Vytorin tablets contain the same percentage of Ezetimibe, which is 10mg. The percentage of Simvastatin in the tablets differs according to the tablet strengths, and the dosage of Vytorin determined by a doctor depends on the individual case or patient being treated.

You should use Vytorin only as recommended by your doctor. The drug can be taken with or without food.

Ezetimibe and Simvastatin Tablets

Myoglobin can cause kidney failure and even what is nortriptyline 10mg used for. This notification was updated on Lexi-Comp March Possible Side Effects This is not a full list of side effects. Please note that the product appearance may vary from actual product received depending on availability. Do not take Vytorin unless it was prescribed to you, even if you have high cholesterol. There are no adequate and well-controlled studies of Vytorin use during pregnancy; however, in rare reports, congenital anomalies were observed following intrauterine exposure to statins. Because HMG-CoA reductase inhibitors statinssuch as simvastatin, decrease cholesterol synthesis and possibly the synthesis of other biologically active substances derived from cholesterol, VYTORIN may cause fetal harm when administered to a pregnant woman. The drug can be taken with or without food, generic for vytorin 10 80. I take Vytorin and my cholesterol has gone down from to In addition, decreased levels of HDL-C are associated with the development of atherosclerosis. Vytorin contains ezetimibe, which reduces cholesterol absorption into the body, and simvastatin, which has been shown to be effective at reducing LDL "bad" cholesterol and triglycerides and at increasing HDL "good" cholesterol. Symptoms may start 1 day to years after starting treatment and resolve within a median of 3 weeks after stopping the statin.

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