Typically, blood will be drawn to check levels of blood cells and to monitor functions of some organ systems, such as the kidneys or liver. Patients may also undergo physical examinations, scans or other measures to assess side effects and response to therapy.

In addition, levels of electrolytes and products of metabolism will be measured frequently to monitor the possibility of developing TLS. Patients will also be monitored for allergic-type reactions that may occur with treatment with allopurinol, including skin abnormalities and liver dysfunction.

What are the most common side effects associated with treatment with allopurinol? Skin rash Abnormalities of the kidneys Diarrhea This is not a complete list of side effects. Some patients may experience other side effects that are not listed here. Patients may wish to discuss with their physician the other less common side effects of this drug, some of which may be serious.

Some side effects may require medical attention. Other side effects do not require medical attention and may go away during treatment. Patients should check with their physician about any side effects that continue or are bothersome. What can patients do to help alleviate or prevent discomfort and side effects? Wear sunscreen and protective clothing and try to minimize sun exposure. Drink plenty of fluids. Patients should ask their physician about the amount of liquid to consume during a day.

Maintain adequate rest and nutrition. Eat small meals frequently to help alleviate nausea. Are there any special precautions patients should be aware of before starting treatment? Patients should tell their physician if they are pregnant, breastfeeding or planning a family in the near future. This drug may cause birth defects. It is important to use some kind of birth control while undergoing treatment. Also, patients may want to talk to their physician if they are considering having children in the future, since some drugs may cause fertility problems.

It is important that patients inform their physician of any pre-existing conditions chicken pox, infection, heart disease, kidney disease, liver disease, lung disease, thyroid disease, etc.

Patients should inform their physician if they have ever had convulsions or seizures. Patients should inform their physician about any other medication they are taking whether prescription or over the counter, including vitamins, herbs, etc. We begin with an abstract posted by Dr. Jordan Dimitrakov in April, Ameliorative effect of allopurinol on nonbacterial prostatitis: J Urol Mar; 3: J Urol Feb; 2: Nonbacterial prostatitis is a common problem in young men. It is a disease that is often recurrent and each episode lasts for several months.

Different causative mechanisms of the disease have been discussed, including identified and unidentified microorganisms, stone formation and psychological factors. We have demonstrated in a previous study that urinary reflux as shown by a high creatinine concentration in prostatic fluid occurs to a varying extent into the prostatic ducts, and this reflux has been related to prostatic pain and urate concentration in expressed prostatic secretion.

We performed a paralled double-blind controlled study of the objective and subjective effects of allopurinol on patients with nonbacterial prostatitis. Twenty patients received placebo, 18 received mg. All patients began medication at the same time regardless of whether the disease was in an active state. No side effects were noted in the treatment groups. Significant effects were noted on the concentrations of serum urate, urine urate, expressed prostatic secretion urate, expressed prostatic secretion xanthine and subjective discomfort.

Allopurinol has a significant, positive effect on nonbacterial prostatitis. It is safe and worthy of trial for all at least a 3- month period at each episode to relieve the symptoms of nonbacterial prostatitis. I think that it could be used in a subset of patients and actuallt some of my patients have benefited from it. Regarding the adverse effects, here's a list of some of them: The most frequent adverse reaction to allopurinol is skin rash.

Skin reactions can be severe and sometimes fatal. Therefore, treatment with allopurinol should be discontinued immediately if a rash develops. Some patients with the most severe reaction also had fever, chills, arthralgias, cholestatic jaundice, eosinophilia and mild leukocytosis or leukopenia.

The explanation for this decrease is not obvious. The incidence of skin rash may be increased in the presence of renal insufficiency. The frequency of skin rash among patients receiving ampicillin or amoxicillin concurrently with allopurinol has been reported to be increased. The most frequent event observed was acute attacks of gout following the initiation of therapy. The explanation for this decrease has not been determined, but it may be due to following recommended usage Respectfully, Jordan Dimitrakov, MD One prostatitis patient, Eliott, believes the use of the drug Allopurinol is curing him of his prostatitis symptoms.

Here is his account: Hi guys, Looks as though I might be cured. At least if you base that on being almost symptom free while on Allopurinol. I may yet find out that there is an anatomical problem I may have to deal with I guess a brief medical history might be in order for those that have not heard my saga.

I am 56 years old, pretty active although I spend too much time sitting in front of a computer , and in good health, other than suffering from chronic non-bacterial prostatitis for the past 15 years. Symptoms that have been with me constantly for the past year include: Frequency of times a night, urgency, pain on urination not a burning, but an aching in the prostate , pain immediately after ejaculation like a cattle prod touching my prostate every few seconds for 30 seconds or so , lower abdominal pain the morning after sex not very bad , sitting pain pain at the prostate moderate , pain at the coccyx pretty severe , pain at the left ischiel knifelike and also pretty severe , every now and then a little pain in the left testicle no big thing , every now and then pain in the left thigh also not very bad.

As many of you are aware, I have always felt that prostatitis is a multifactorial disease. I think that feeling strongly about this gave me the freedom to search for causes other than the traditional pathogens.

That and the fact that I had read about a number of men that had severe prostatitis pain, and when their prostates were removed because of Pca, they still had all their symptoms.

Anyway what prompted my research was an eleventh hour last ditch effort to avoid a biopsy. My PSA last July was 5. Three and a half months later 5. TRUS turns up a hypoechoic area. Can't tell if it's a tumor or prostatitis lesion.

TRUS also shows a fair amount of stones. Uro who wants to avoid a BX and the possible can of worms it opens as much as I do, gives me 30 days worth of Cipro in the hopes that we can get my PSA down.

Lot's of luck Elliott! From previous research I knew that stones are said to sometimes be little warehouses for bacteria, but I wanted to see what else I could find out about them.

A little research turned up a paper that said upon analysis many stones were found to be made up of the same ingredients as those found in urine Decided to do a search and see if I could find a link between urine and prostatitis.

Found a clinical trial from Sweden which purported to show that urine refluxing into the prostatic ducts was causing prostatitis in a number of men.

I faxed the abstract to my urologist who said "No way, that's very potent stuff". Talks about Steven Johnson syndrome and someone dying on it etc, etc. Rob Blackburn my Aussie pharmacist E-mails me the complete paper, which I fax to the urologist, and he says I go that route for two weeks and then obtain some more covertly sorry if you're listening doc and every other day use mg.

Several weeks later and sooner than it should have happened I am pain free.

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