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A vision that unleashes value Zydus shall be a leading global healthcare provider with a robust product pipeline; Opening up new pathways through innovation and quality excellence, we shall be a research-based company by Growth Record — From a turnover of Rs. The group registered a turnover of over Rs. Ranked the 4th largest pharmaceutical company in India as compared to the 16th rank in The group is today a global, integrated healthcare provider with strengths all along the pharmaceutical value chain.

We improved our ranking by two places and are currently the 6th largest player in the IPM. We registered particularly strong growth in Respiratory, Anti-Diabetic, Gastro-Intestinal and Gynaecology therapeutic areas and improved upon our market share during the year. We have gained a distinctive edge over the competition through multiple strategic alliances with multinational pharma players which helped us to outperform the market on new product launches throughout the year.

It is also a matter of great pride for us to see 9 of our brands feature amongst the Top brands of IPM which includes an addition of 4 new brands in FY alone. Paediatric use should only be carried out by physicians experienced in the treatment of paediatric hyperlipidaemia and patients should be re-evaluated on a regular basis to assess progress.

For patients aged 10 years and above, the recommended starting dose of atorvastatin is 10mg per day with titration up to 20mg per day. Titration should be conducted according to the individual response and tolerability in paediatric patients. Safety information for paediatric patients treated with doses above 20 mg, corresponding to about 0.

There is limited experience in children between years of age see section 5. Atorvastatin is not indicated in the treatment of patients below the age of 10 years. Method of administration Atorvastatin 10mg Film coated Tablets is for oral administration. Each daily dose of atorvastatin is given all at once and may be given at any time of day with or without food.

Patients who develop any signs or symptoms suggestive of liver injury should have liver function tests performed. Patients who develop increased transaminase levels should be monitored until the abnormality ies resolve.

Should an increase in transaminases of greater than 3 times the upper limit of normal ULN persist, reduction of dose or withdrawal of Atorvastatin 20mg Film coated Tabletsis recommended see section 4.

Stroke Prevention by Aggressive Reduction in Cholesterol Levels SPARCL In a post-hoc analysis of stroke subtypes in patients without coronary heart disease CHD who had a recent stroke or transient ischemic attack TIA there was a higher incidence of hemorrhagic stroke in patients initiated on atorvastatin 80 mg compared to placebo.

The increased risk was particularly noted in patients with prior hemorrhagic stroke or lacunar infarct at study entry. For patients with prior hemorrhagic stroke or lacunar infarct, the balance of risks and benefits of atorvastatin 80 mg is uncertain, and the potential risk of hemorrhagic stroke should be carefully considered before initiating treatment see section 5.

Before the treatment Atorvastatin should be prescribed with caution in patients with pre-disposing factors for rhabdomyolysis. A CK level should be measured before starting statin treatment in the following situations: Creatine kinase measurement Creatine kinase CK should not be measured following strenuous exercise or in the presence of any plausible alternative cause of CK increase as this makes value interpretation difficult.

Whilst on treatment - Patients must be asked to promptly report muscle pain, cramps, or weakness especially if accompanied by malaise or fever. Concomitant treatment with other medicinal products Risk of rhabdomyolysis is increased when atorvastatin is administered concomitantly with certain medicinal products that may increase the plasma concentration of atorvastatin such as potent inhibitors of CYP3A4 or transport proteins e.

The risk of myopathy may also be increased with the concomitant use of gemfibrozil and other fibric acid derivates, erythromycin, niacin and ezetimibe. C-ZIDTZ is indicated for the treatment of patients with infections caused by susceptible strains of organisms in the following diseases: DHA-Cal is a combination of Calcium Carbonate and Docosahexaenoic Acid recommended during pregnancy for optimal fetal brain and skeletal development.

The launch of Reatix kit reiterates Emcure's efforts in bringing patient friendly combinations that may enhance compliance in chronic therapies. As the name suggest the pill offers the convenience of one tablet a day dosing which will enhance patient compliance to therapy. The kit provides newer option in initiating antiretroviral therapy for treatment-naive patients. Emcure is the first one to introduce this novel combination in the market. Full 24 Syrup Full 24 syrup is a Multivitamin and Multimineral suspension which reduces the incidence of infection and rapidly corrects micronutrient deficiency.

Full 24 Inj Full 24 Inj contain Methylcobalamin mcg which helps in faster regeneration, repair and remyelination of degenerating nerve terminals. Dilsave Dilsave contain Dronedarone mg tablets, which is the most recent drug to treat Paroxysmal or Persistent Atrial Fibrillation and Atrial Flutter.

Encicarb Supportive care is one of the most important co-treatment for the successful outcome of cancer patient management. They may require Iron supplementation, Erythropoietin Stimulating Agents, and blood transfusion. Blood transfusion is advised when the anemia is severe and there are known disadvantages of it.

Of late, ESA usage in oncology has been reduced due to some concerns on increased risk of venous thromboembolism. IV iron has recently been recommended by guidelines for use in cancer associated anemia due to iron deficiency. There are several IV iron preparations.

Ferric Carboxymaltose Encicarb is the closest to the ideal iron preparation and has the best tolerability profile as compared to others with the unique advantage of giving a total dose of a maximum mg within a span of 15min. Carmustine was launched more than 30 years back for the treatment of Brain Tumors, Lymphomas, Multiple Myeloma and Gastric Cancer, however this molecule was not marketed in India and thus some cancer patients were not able to get this drug.

The clinical significance of this effect is uncertain and not sufficient to preclude their use. NSAIDS can attenuate the antihypertensive effect of both angiotensin II antagonists and hydrochlorothiazide when administered simultaneously.

Therefore, monitoring of renal function at the beginning of the treatment is recommended, as well as adequate hydration of the patient. Interactions related to valsartan Dual blockade of the Renin-Angiotensin-Aldosterone System RAAS with ARBs, ACEIs, or aliskiren Clinical trial data has shown that dual blockade of the renin-angiotensin-aldosterone-system RAAS through the combined use of ACE inhibitors, angiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotension, hyperkalaemia and decreased renal function including acute renal failure compared to the use of s single RAAS-acting agent see section 4.

Concomitant use not recommended Potassium-sparing diuretics, potassium supplements, salt substitutes containing potassium and other substances that may increase potassium levels. If a medicinal product that affects potassium levels is considered necessary in combination with valsartan, monitoring of potassium plasma levels is advised. The clinical relevance of this finding is unknown.

Co-administration of inhibitors of the uptake transporter eg. Exercise appropriate care when initiating or ending concomitant treatment with such drugs. No interaction In drug interaction studies with valsartan, no interactions of clinical significance have been found with valsartan or any of the following substances: Digoxin and indomethacin could interact with the hydrochlorothiazide component of Co-Diovan see interactions related to hydrochlorothiazide.

Interactions related to hydrochlorothiazide Concomitant use requiring caution Medicinal products affecting serum potassium level The hypokalaemic effect of hydrochlorothiazide may be increased by concomitant administration of kaliuretic diuretics, corticosteroids, laxatives, ACTH, amphotericin, carbenoxolone, penicillin G, salicylic acid and derivatives.

If these medicinal products are to be prescribed with the hydrochlorothiazide-valsartan combination, monitoring of potassium plasma levels is advised see section 4. Medicinal products that could induce torsades de pointes Due to the risk of hypokalaemia, hydrochlorothiazide should be administered with caution when associated with medicinal products that could induce torsades de pointes, in particular Class Ia and Class III antiarrhythmics and some antipsychotics.

Medicinal products affecting serum sodium level The hyponatraemic effect of diuretics may be intensified by concomitant administration of drugs such as antidepressants, antipsychotics, antiepileptics, etc. Caution is advised in long-term administration of these drugs.

Digitalis glycosides Thiazide-induced hypokalaemia or hypomagnesaemia may occur as undesirable effects favouring the onset of digitalis-induced cardiac arrhythmias see section 4. Calcium salts and vitamin D Administration of thiazide diuretics, including hydrochlorothiazide, with vitamin D or with calcium salts may potentiate the rise in serum calcium.

Concomitant use of thiazide type diuretics with calcium salts may cause hypercalcaemia in patients pre-disposed for hypercalcaemia e.

Antidiabetic agents oral agents and insulin Thiazides may alter glucose tolerance. Dose adjustment of the antidiabetic medicinal product may be necessary. Metformin should be used with caution because of the risk of lactic acidosis induced by possible functional renal failure linked to hydrochlorothiazide. Beta blockers and diazoxide Concomitant use of thiazide diuretics, including hydrochlorothiazide, with beta blockers may increase the risk of hyperglycaemia. Thiazide diuretics, including hydrochlorothiazide, may enhance the hyperglycaemic effect of diazoxide.

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The content on this site is offered only as information and it does not constitute solicitation or provision 5mg Medical advice. Thiazides should be discontinued before carrying out tests for parathyroid function. Interactions related to valsartan Dual blockade of the Renin-Angiotensin-Aldosterone System RAAS with ARBs, ACEIs, or aliskiren Clinical trial data has shown that dual blockade of the renin-angiotensin-aldosterone-system RAAS through amlodipine combined use of ACE inhibitors, angiotensin II receptor blockers or aliskiren is associated with a higher frequency of adverse events such as hypotension, hyperkalaemia and decreased renal amlodipine including acute renal failure compared to the use of s single RAAS-acting agent see section 4. Hydrochlorothiazide crosses the placenta. If dual blockade therapy is considered absolutely necessary, amlodipine 5mg od, this should only occur under specialist supervision and subject to frequent close monitoring of renal function, electrolytes and blood pressure. The antihypertensive effect is substantially present within 2 weeks, amlodipine 5mg od. Digitalis glycosides Thiazide-induced hypokalaemia or hypomagnesaemia may occur as undesirable effects favouring the onset of digitalis-induced cardiac arrhythmias 5mg section 4, amlodipine 5mg od. As we embark on our journey next year, amlodipine 5mg od, we are conscious of the challenges that lie ahead of us. Heterozygous familial hypercholesterolaemia Patients should ciprofloxacin ratiopharm 500mg packungsbeilage started with Atorvastatin 5mg Film coated Tablets daily. When driving 5mg or operating machines it should be amlodipine into account that occasionally dizziness or weariness may occur. Amlodipine cannot guarantee that the information on this Site is accurate, amlodipine 5mg od, complete or up-to-date, amlodipine 5mg od.


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In exceptional circumstances, where prolonged systemic fusidic acid is amlodipine, e. Full 24 Inj Full 24 5mg contain Methylcobalamin mcg which helps in faster regeneration, repair and remyelination of degenerating nerve terminals. As a leading healthcare provider, it aims to become a global research based pharmaceutical company by Lyophilized powder of Cetrorelix Acetate Injection used in the mature Infertility market. The risk of these events may therefore be increased with concomitant use of ezetimibe and atorvastatin. A therapeutic response is evident within 2 weeks, and the maximum therapeutic response is usually achieved within 4 weeks, amlodipine 5mg od. Marked hypercalcaemia may be evidence of underlying hyperparathyroidism, amlodipine 5mg od. The success in the domestic market is an outcome of the dedication and expertise of our team of over 6, front line staff who remain committed amlodipine growth through 5mg customer engagement. Whilst on treatment - Patients must be asked to promptly report muscle pain, cramps, or weakness especially if accompanied by malaise or fever.


Co-Diovan 80/12.5 mg, 160/12.5 mg, 160/25 mg Tablets

We continue to strengthen our business by building new and fast growing therapeutic areas such as Gynaecology, Dermatology, Urology and Oncology, which will bolster our growth prospects for future. It is indicated as adjunct to specific therapy for osteoporosis and in situations requiring therapeutic supplementation e, amlodipine 5mg od. Paediatric population Developmental safety in the paediatric population has not been established see section 4. Name of the medicinal product Atorvastatin 10mg Film-coated Tablets 2. Due to the dual interaction mechanism of rifampin, cytochrome P 5mg induction and inhibition of hepatocyte uptake transporter OATP1B15mg co-administration of amlodipine with rifampin is recommended, as delayed administration of atorvastatin after administration of rifampin has been associated with a significant amlodipine in atorvastatin plasma concentrations. If treatment with systemic fusidic acid is necessary, amlodipine 5mg od, atorvastatin treatment should be discontinued throughout the duration of the fusidic acid treatment. Patients taking digoxin should be monitored appropriately. Growth Record — From a turnover of Rs. The effect of inhibition of hepatic uptake transporters on atorvastatin concentrations in hepatocytes is unknown. Adjustment of dose should be made at intervals of 4 weeks or more. The group has forged meaningful partnerships with its key stakeholders both internal and external, partners in progress and the community at large.


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