All-cause mortality was similar in the valsartan Combining valsartan with captopril did not add further benefit over captopril alone.

There was no difference between valsartan and captopril in all-cause mortality based on age, gender, race, baseline therapies or underlying disease. Valsartan was also effective in prolonging the time to and reducing cardiovascular mortality, hospitalisation for heart failure, recurrent myocardial infarction, resuscitated cardiac arrest, and non-fatal stroke secondary composite endpoint. The safety profile of valsartan was consistent with the clinical course of patients treated in the post-myocardial infarction setting.

Regarding renal function, doubling of serum creatinine was observed in 4. Discontinuations due to various types of renal dysfunction occurred in 1. An assessment of renal function should be included in the evaluation of patients post-myocardial infarction. Irrespective of treatment, mortality was lower in the group of patients treated with a beta blocker, suggesting that the known beta blocker benefit in this population was maintained in this trial.

The mean duration of follow-up was nearly two years. The study had two primary endpoints: The primary benefit was a Results appearing to favour placebo composite mortality and morbidity was Composite mortality and morbidity risk was significantly reduced by In the overall Val-HeFT population, valsartan treated patients showed significant improvement in NYHA class, and heart failure signs and symptoms, including dyspnoea, fatigue, oedema and rales compared to placebo.

Patients treated with valsartan had a better quality of life as demonstrated by change in the Minnesota Living with Heart Failure Quality of Life score from baseline at endpoint than placebo.

Ejection fraction in valsartan treated patients was significantly increased and LVIDD significantly reduced from baseline at endpoint compared to placebo. ONTARGET was a study conducted in patients with a history of cardiovascular or cerebrovascular disease, or type 2 diabetes mellitus accompanied by evidence of end-organ damage.

Given their similar pharmacodynamic properties, these results are also relevant for other ACE inhibitors and angiotensin II receptor blockers. ACE inhibitors and angiotensin II receptor blockers should therefore not be used concomitantly in patients with diabetic nephropathy. The study was terminated early because of an increased risk of adverse outcomes. How much to take For hypertension, the usual dose is one 80 mg tablet once a day. If your blood pressure is still too high after 4 weeks, your doctor may increase the dose to mg once a day, or from mg to mg once a day.

If your blood pressure is still too high, your doctor may add a different type of blood pressure lowering medicine. For heart failure the usual starting dose is 40 mg twice daily. Your doctor may increase the dose gradually up to one mg tablet twice daily. Following a heart attack, treatment is generally started at a dose of 20 mg half a 40 mg tablet twice daily.

Your doctor may increase the dose gradually up to mg twice daily. When to take it When you take the first tablet from the pack of Diovan, take the one marked with the correct day of the week e. Diovan comes in a calendar pack with the days of the week marked on it to help you remember to take your tablet each day.

This also helps you remember to take it, especially if you take it as part of your usual routine e. How to take it Swallow the tablet with a full glass of water. Always take it in the same way in relation to food. It does not matter if you take it after food or on an empty stomach, as long as you take it the same way each day.

If your stomach is upset after taking Diovan, always take it after a meal e. How long to take it Take this medicine until your doctor tells you to stop even if you feel quite well. It will take at least 4 weeks for this medicine to have its full effect.

After that, it will be continued for as long as your doctor thinks it is needed. Keep the telephone numbers for these places handy. Too much Diovan may make you feel dizzy, lightheaded or faint. Its empirical formula is C24H29N5O3, its molecular weight is Valsartan is a white to practically white fine powder. It is soluble in ethanol and methanol and slightly soluble in water. Angiotensin II is the principal pressor agent of the renin-angiotensin system, with effects that include vasoconstriction, stimulation of synthesis and release of aldosterone, cardiac stimulation, and renal reabsorption of sodium.

Diovan valsartan blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively blocking the binding of angiotensin II to the AT1 receptor in many tissues, such as vascular smooth muscle and the adrenal gland. Its action is therefore independent of the pathways for angiotensin II synthesis. There is also an AT2 receptor found in many tissues, but AT2 is not known to be associated with cardiovascular homeostasis.

Valsartan has much greater affinity about 20,fold for the AT1 receptor than for the AT2 receptor. The increased plasma levels of angiotensin II following AT1 receptor blockade with valsartan may stimulate the unblocked AT2 receptor. The primary metabolite of valsartan is essentially inactive with an affinity for the AT1 receptor about oneth that of valsartan itself. Blockade of the renin-angiotensin system with ACE inhibitors, which inhibit the biosynthesis of angiotensin II from angiotensin I, is widely used in the treatment of hypertension.

Whether this difference has clinical relevance is not yet known. Valsartan does not bind to or block other hormone receptors or ion channels known to be important in cardiovascular regulation.

Blockade of the angiotensin II receptor inhibits the negative regulatory feedback of angiotensin II on renin secretion, but the resulting increased plasma renin activity and angiotensin II circulating levels do not overcome the effect of valsartan on blood pressure. No information on the effect of larger doses is available. Removal of the negative feedback of angiotensin II causes a 2- to 3-fold rise in plasma renin and consequent rise in angiotensin II plasma concentration in hypertensive patients.

Minimal decreases in plasma aldosterone were observed after administration of valsartan; very little effect on serum potassium was observed. In multiple-dose studies in hypertensive patients with stable renal insufficiency and patients with renovascular hypertension, valsartan had no clinically significant effects on glomerular filtration rate, filtration fraction, creatinine clearance, or renal plasma flow.

May be taken without regard to food. Take missed doses as soon as remembered if not almost time for next dose; do not double doses. Warn patient not to discontinue therapy unless directed by health care professional. Caution patient to avoid salt substitutes containing potassium or foods containing high levels of potassium or sodium unless directed by health care professional.

Caution patient to avoid sudden position changes to decrease orthostatic hypotension.

DIOVAN 40 MG TABLETS

However, get medical help right away if diovan notice any symptoms of a serious allergic reactionincluding: Diovan does not affect the apparent clearance in heart failure patients. Since there is no tablet on ACE and no potentiation of bradykinin or substance P, angiotensin II antagonists are unlikely to be associated with coughing. Overall, the three dose levels of valsartan low, medium and diovan significantly reduced systolic blood pressure by -8,diovan 40mg tablets, mm Hg from the baseline, respectively. Consequently, dose adjustment is not required in patients with mild-to-moderate renal dysfunction. There were two primary end points, diovan 40mg tablets, both assessed as time to first event: Composite tablet and tablet risk was significantly reduced by Hypertrophy of the renal juxtaglomerular cells was also seen in both species. Diovan was generally well tolerated in children 6 diovan 16 40mg and the adverse experience profile was similar to 40mg described for adults. These results are plavix brand name price in 40mg following table. It belongs to a group of drugs called angiotensin II receptor antagonists that keeps blood vessels from narrowing and thereby lowers blood pressure and improves blood flow. This product may contain inactive tablets, which can cause allergic reactions or 40mg problems. The steady-state volume of distribution of valsartan after intravenous administration is about 17 litres, indicating that valsartan does not distribute into tissues extensively, diovan 40mg tablets.

Diovan the Brand-Name Form of Valsartan - Overview

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