Follow your doctor's instructions carefully. Do not take more or less medication or take it more frequently than prescribed. Your condition will not improve any faster and your risk of side effects will increase. Use Imipramine 25mg regularly in order to get the most benefit from it. To help you remember, use it at the same time s each day. Imipramine 25mg does not work right away. It may take up to 3 weeks before you experience the full benefits if you are taking Imipramine 25mg for depression.
It is important to continue taking Imipramine 25mg even if you feel well. Do not suddenly stop taking Imipramine 25mg without consulting your doctor. Some conditions may become worse when the drug is abruptly stopped. Your dose may need to be gradually decreased. When used for an extended period in children for bed-wetting, Imipramine 25mg may not work as well and may require different dosing. Talk with the doctor if Imipramine 25mg stops working well.
Inform your doctor if your condition persists or worsens. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember that your doctor has prescribed Imipramine 25mg because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using Imipramine 25mg do not have serious side effects. Tell your doctor right away if any of these unlikely but serious side effects occur: Administration of a tranquilizer may be useful in controlling such episodes.
An activation of the psychosis may occasionally be observed in schizophrenic patients and may require reduction of dosage and the addition of a phenothiazine.
Concurrent administration of Tofranil with electroshock therapy may increase the hazards; such treatment should be limited to those patients for whom it is essential , since there is limited clinical experience.
Patients taking imipramine hydrochloride should avoid excessive exposure to sunlight since there have been reports of photosensitization. Both elevation and lowering of blood sugar levels have been reported with imipramine hydrochloride use. Imipramine hydrochloride should be used with caution in patients with significantly impaired renal or hepatic function.
Patients who develop a fever and a sore throat during therapy with imipramine hydrochloride should have leukocyte and differential blood counts performed. Imipramine hydrochloride should be discontinued if there is evidence of pathological neutrophil depression. Prior to elective surgery , imipramine hydrochloride should be discontinued for as long as the clinical situation will allow.
Information For Patients Prescribers or other health professionals should inform patients, their families, and their caregivers about the benefits and risks associated with treatment with imipramine hydrochloride and should counsel them in its appropriate use. The prescriber or health professional should instruct patients, their families, and their caregivers to read the Medication Guide and should assist them in understanding its contents.
Consult your doctor before breast-feeding. Store the US product in a tightly closed container at room temperature between degrees F degrees C away from light and moisture. Store the Canadian product in a tightly closed container at room temperature between Do not store in the bathroom. Keep all medicines away from children and pets. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed.
Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Do not start, stop, or change the dosage of any medicines without your doctor's approval. Some products that may interact with this drug include: Taking MAO inhibitors with this medication may cause a serious possibly fatal drug interaction.
Avoid taking MAO inhibitors isocarboxazid, linezolid, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, tranylcypromine during treatment with this medication. Most MAO inhibitors should also not be taken for two weeks before and after treatment with this medication.
Ask your doctor when to start or stop taking this medication. Other medications can affect the removal of imipramine from your body, which may affect how imipramine works. Examples include barbiturates such as phenobarbital , cimetidine, cisapride, haloperidol, certain drugs for heart rhythm such as flecainide, propafenone , halofantrine, certain HIV protease inhibitors such as fosamprenavir , phenothiazines such as thioridazine , pimozide, certain anti-seizure drugs such as phenytoin , terbinafine, trazodone, among others.
Many drugs besides imipramine may affect the heart rhythm QT prolongation , including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics such as erythromycin , sparfloxacin, among others. Tofranil general information What is Tofranil used for?
Tofranil tablets 25mg are used to treat used to depression also known as clinical depression or Major Depressive Disorder MDD , to help relieve symptoms of depressive illness, including anxiety, loss of interest in usual activities, disturbed sleep, change in appetite, fatigue, feelings of worthlessness or guilt, difficulty thinking or concentrating, and recurrent thoughts of suicide. Tofranil 25 is also used to treat depression associated with personality disorders that affect the affect daily activities, perception of everyday situations and relationships with others; also depression associated with chronic alcoholism.
How does Tofranil work? Tofranil tablets 25mg contains imipramine, a tricyclic antidepressant that has several pharmacological properties, due to its interaction with several chemicals and numerous neurotransmitter systems that are thought to be involved in depression and other psychiatric disorders.
Anyone considering the use of imipramine hydrochloride or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older.
Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior.
Families and caregivers should be advised of the need for close observation and communication with the prescriber. Imipramine hydrochloride is not approved for use in pediatric patients. Once you are feeling better, your doctor may be able to slowly reduce the dose, usually down to 50 to mg each day.
For bed-wetting, the usual dose for children aged years is 20 to 30 mg each day. For children aged years the dose is 25 to 50 mg each day and for children aged over 12 years, the dose is up to 75 mg each day. The higher doses are usually used if bed-wetting does not improve after a week of treatment at a lower dose. If you are older than 65 years, your doctor will probably start with a low dose e. The dose is gradually increased over about ten days to 30 to 50 mg each day and kept at that dose for the rest of your treatment.
When to take it For depression, take the tablets in 2 or 3 doses spread over the day unless your doctor advises you otherwise.
If the tablets make you sleepy, your doctor may suggest that you take one dose at night to help you sleep well. For bed-wetting, take the tablets as a single dose after the evening meal unless your doctor advises you otherwise. If bed-wetting tends to happen early in the night, your doctor may advise you to take part of the dose earlier e.
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